一、基本信息

姓名：李東堯

學曆/學位：研究生/工學博士

職務職稱：副教授

所在部門：bevictor伟德官网生物工程系

通訊地址：保定市樂凱南大街2596号bevictor伟德官网

郵政編碼：071001

聯系電話：0312-7528423

電子郵箱：lidongyao@hebau.edu.cn

二、學習工作經曆

2006.09～2010.06 河北北方學院 食品科學與工程 學士

2011.09～2020.08 江南大學 食品科學與工程 碩博

攻讀博士學位期間，主要負責陳衛院士團隊生物信息服務器PowerEdge R910及R920的運維，曾經手幾十例腸道/發酵食品體系的菌群多樣性分析工作；并協助管理氣相與液相色譜、四極杆質譜與Orbitrap高分辨質譜等大型儀器。接受過多家培訓機構有關多組學聯合分析的面授培訓，以及Illumina與Termo Fisher Scientific等公司有關高通量測序與代謝組學的實驗操作與分析軟件培訓，熟悉Perl、Python、R語言編程，以及shell腳本等大型運算流程pipeline的搭建。論文影響因子累計77.547，總被引頻次達779次；參與2項國家自然科學基金資助課題，主要承擔組學及生物信息分析工作。

2020.11至今 bevictor伟德官网 生物工程系 副教授

三、主講課程及研究方向

1、主講課程：現代食品生物技術、細胞工程、發酵工程與設備

2、研究方向：食品自然發酵過程中群落結構、功能及代謝網絡的演替；發酵食品功能性組分對腸道微生物及人體疾病健康的影響；多組學聯合分析、深度挖掘發酵食品新資源

四、代表性論文

1. Copper inhibits post-acidification of yogurt and affects its flavor: A study based on the Cop operon. Journal of Dairy Science. 2023, 106(2): 897 - 911. (co-first author, IF = 4.225)

2. Effect of fructo-oligosaccharides on the colonization of Lactobacillus rhamnosus AS 1.2466^T in the gut of mice. Food Science and Human Wellness. 2023, 12(2): 607 - 613. (IF = 8.022)

3. Niacin inhibits post-acidification of yogurt based on the mining of LDB_RS00370 biomarker gene. Food Research International. 2022, 162(A): 111929. DOI: 10.1016/j.foodres.2022.111929. (co-first author, IF = 7.425)

4. Mechanism of gastrointestinal adaptability and antioxidant function of infant‑derived Lactobacillus plantarum BF_15 through genomics. Food Science and Biotechnology. 2022, 31(11): 1451 - 1462. (co-first author, IF = 3.231)

5. Global transcriptomic analysis of Lactobacillus delbrueckii subsp. bulgaricus ATCC11842 reveals the role of LDB_RS05285 in the post-acidification of yogurt. Food & Function. 2021, 12(19): 9077 - 9086. (co-first author, IF = 6.317)

6. Potential Functions of the Gastrointestinal Microbiome Inhabiting the Length of the Rat Digest Tract. International Journal of Molecular Sciences. 2019, 20(5), 1232. DOI: 10.3390/ijms20051232. (first author, IF = 6.208)

7. Microbial Biogeography and Core Microbiota of the Rat Digestive Tract. Scientific Reports. 2017, 7, 45840. DOI: 10.1038/srep45840. (first author, Top 100 in Microbiology, Google Scholar 130 citations)

8. Lactulose Differently Modulates the Composition of Luminal and Mucosal Microbiota in C57BL/6J Mice. Journal of Agricultural and Food Chemistry. 2016, 64(31), 6240 - 6247. (co-first author, Google Scholar 97 citations)

9. Metagenomic Insights into the Effects of Fructo-oligosaccharides (FOS) on the Composition of Fecal Microbiota in Mice. Journal of Agricultural and Food Chemistry. 2015, 63(3): 856 - 863. (co-first author, Google Scholar 94 citations)

10. In Vitro Fermentation of Lactulose by Human Gut Bacteria. Journal of Agricultural and Food Chemistry. 2014, 62(45): 10970 - 10977. (co-first author, Google Scholar 50 citations)